Clinical Research Directory

Effect of a Preoperative Oral Collagen-Based Formulation on Dermal Collagen Content, Wound Outcomes, and Scar Quality

This single-center, randomized, placebo-controlled trial evaluated whether approximately 8 weeks of preoperative supplementation with a 10-g daily collagen-based oral formulation affected dermal collagen content and postoperative outcomes in adults aged 18-65 years who had previously undergone metabolic/bariatric surgery and were scheduled for breast and/or abdominal body-contouring surgery. The active formulation contained hydrolyzed bovine collagen peptides, vitamin C from acerola, and hyaluronic acid; the comparator was 10 g of food-grade starch. Tissue was obtained only from skin routinely removed during the planned operation. The primary endpoint was dermal collagen area fraction measured in Picrosirius-red-stained excised skin. Secondary outcomes included collagen I and III immunohistochemical area fractions, epidermal thickness, TGF-β1 and MMP-1 expression, serum hydroxyproline, postoperative wound complications, and total Vancouver Scar Scale scores at 3 and 6 months. A total of 111 participants were randomized, 55 to the collagen-based formulation and 56 to placebo. Surgical and primary tissue assessments were completed on 15 December 2025, and final 6-month follow-up was completed on 20 May 2026.

Effects of Oral Collagen Drinks on Human Skin

The objective of this study is to evaluate the effect of oral collagen drink and MAXI collagen drink on human skin condition improvement.