Clinical Research Directory

Isokinetic Training With Blood Flow Restriction for Patellofemoral Pain Syndrome

This randomized controlled trial aims to investigate the effects of isokinetic training combined with blood flow restriction (BFR) in individuals with patellofemoral pain syndrome (PFPS).

MRI Study of Musculoskeletal Function

This study will use magnetic resonance imaging (MRI) and ultrasound images to study how muscles, tendons, and bones work together to cause motion. The procedure is one of several tools being developed to characterize normal and impaired musculoskeletal function, with the goal of developing improved methods of diagnosis and treatment of movement disorders. Healthy normal volunteers must be age 5 to unlimited, with or without joint impairment, may be eligible for this study. Volunteers with joint impairment may not have serious injury to the joint being studied, previous surgery on the joint being studied, or extreme pain at the joint being studied. MRI uses a strong magnet and radio waves to create images of the inside of the body. The subject lies on a long narrow couch inside a metal cylinder (the scanner) for up to 3 hours while the scanner gathers data. Earplugs are worn to muffle loud noises caused by electrical switching of radiofrequency circuits used in the scanning process. A special pad or tube may be placed over or around the region being scanned to improve the quality of the data. The subject will be asked to repeatedly move a specific joint, such as the knee, for brief periods, usually less than 5 minutes. The subject can communicate via intercom with the person performing the study at all times during the procedure, and may request to stop the study at any time.

AI Based Telerehabilitation for Patellofemoral Pain Syndrome

Patellofemoral pain syndrome (PFPS) is a common cause of anterior knee pain in young, active adults and is often aggravated by prolonged sitting, stair use, squatting, and running. Exercise-based physiotherapy is the standard first-line treatment, but access to regular in-person supervision can be limited. This study compares two ways of delivering the same evidence-based exercise programme for PFPS: AI-based telerehabilitation, delivered remotely through the Physitrack platform with AI-assisted movement screening (MediaPipe), and conventional face-to-face physiotherapy. The study aimed to determine whether AI-based telerehabilitation is as effective as, or more effective than, conventional physiotherapy in reducing pain and improving physical function, and to evaluate how usable participants found the telerehabilitation platform

Motor Control Retraining vs Close Kinetic Chain Exercises for Pain, Function and Vastus Medialis Oblique Strength in Patients With Patellofemoral Pain Syndrome

This study compares two treatments - motor control retraining and close kinetic chain exercises - to improves the pain, VMO strength, knee function. Fifty participants out of which 4 dropped out; will be randomly assigned to receive either motor control retraining or close kinetic chain exercises training for 45 minutes per session, three times per week, for six weeks. Pain intensity will be measured using the visual analogue scale. Knee function will be measured using Kujala anterior knee pain scale. Vastus medialis oblique strength will be measured using digital dynamometer. Dynamic knee valgus will be measured using Kinovea-2D video analysis. Q-angle will be measured using manual goniometer. Patellar maltracking will be measured using combined assessment of dynamic knee valgus and q-angle. This study aims to determine which treatment produces greater improvements, which may help physiotherapists choose more effective treatments for patient with patellofemoral pain syndrome in Pakistan.

Effects of Isometric, Isotonic, and Eccentric VMO Exercises in Patellofemoral Pain Syndrome

Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition characterized by anterior knee pain, especially during activities such as stair climbing, squatting, running, and prolonged sitting. Weakness or delayed activation of the vastus medialis oblique (VMO) muscle is considered an important contributing factor in the development of PFPS. This study aims to compare the effects of three different types of VMO strengthening exercises (isometric, isotonic, and eccentric) applied within the terminal knee extension range (0-30°) on pain, functional performance, and muscle architecture in individuals with PFPS. Participants will be randomly assigned to one of three exercise groups. All participants will receive a standardized physiotherapy program, including heat therapy, TENS, and therapeutic ultrasound, followed by group-specific VMO strengthening exercises. The intervention will be performed three times per week for 8 weeks. Outcomes will be assessed before and after the intervention and will include pain intensity (Visual Analog Scale), functional performance (WOMAC, 30-second sit-to-stand test, and stair test), and muscle architecture parameters measured by ultrasound imaging. The results of this study are expected to provide evidence for optimizing rehabilitation strategies in individuals with PFPS.

Muscle Strength Loss and Its Effect on Knee Cap Motion in Volunteers With Anterior Knee Pain

Background: \- Researchers are interested in how the muscles affect the movement of the knee cap. These muscles may be related to different kinds of knee pain that are not caused by an injury or a disease. Imaging studies such as magnetic resonance imaging (MRI) can be used to look at these muscles. To study these muscles and how they move, researchers will use MRI to look at healthy individuals and individuals with knee cap pain. Objectives: \- To study how changes to the muscles around the knee can influence knee pain. Eligibility: * Individuals between 18 to 55 years of age who have knee cap pain that cannot be explained by a specific injury or disease. * Healthy volunteers between 18 and 55 years of age. Design: * Participants will be screened with a physical exam and medical history. * This study requires two visits. Each visit will use standard MRI sequences to take images of the knee in motion and at rest. * On the first visit, the MRI scan will look at the knee in its natural state. Participants will move the knee up and down for 1 to 3 minutes at a time during the scan. * On the second visit, a local anesthetic agent will be injected into the muscle of the thigh. The anesthetic will block this muscle from generating force for 2 or 3 hours. Participants will move the knee up and down for 1 to 3 minutes at a time during the MRI scan.

Effect of Adding Inguinal Ligament Mobilization to Talonavicular Joint Mobilization on Patellofemoral Pain Syndrome

This study will be conducted to: * To assess the effect of adding the inguinal ligament mobilization to talonavicular joint mobilization on pain intensity subjects with PFPS * To assess the effect of adding the inguinal ligament mobilization to talonavicular joint mobilization on pain threshold in subjects with PFPS. * To assess the effect of adding the inguinal ligament mobilization to talonavicular joint mobilization on knee function in subjects with PFPS . * To assess the effect of adding the inguinal ligament mobilization to talonavicular joint mobilization on Q angle in subjects with PFPS .

Dynamic Q Angle and Core Endurance in Adolescent Athletes With Patellofemoral Pain Syndrome

This observational, cross-sectional study aimed to compare dynamic Q-angle, trunk/core endurance, and lower-extremity flexibility between elite adolescent female and male sprinters with and without patellofemoral pain syndrome (PFPS). Participants were classified according to sex and PFPS status. Dynamic Q-angle was assessed during a standardized step-down task, trunk endurance was evaluated using McGill flexion, extension, and lateral endurance tests, and lower-extremity flexibility was assessed using the Straight Leg Raise, Modified Thomas, and Ober tests. The study also examined whether sex and PFPS status were independently associated with dynamic Q-angle. No therapeutic or experimental intervention was administered.

Effect of Short Foot Exercise Combined With Focused Hip and Knee Exercises on Pain, Q Angle and Functional Outcomes in Female Patients With Patellofemoral Pain Syndrome

This randomized controlled trial aims to evaluate the effectiveness of short foot exercises combined with focused hip and knee strengthening on pain, Q-angle, and functional outcomes in female patients with patellofemoral pain syndrome (PFPS). Thirty-eight participants aged 18-45 years will be randomly assigned to either an experimental group (short foot + hip and knee exercises) or a control group (hip and knee exercises only) for a 6-week supervised rehabilitation program.

Popliteus Muscle Release Versus Patellofemoral Mobilization in Patellofemoral Pain Syndrome

This study will be conducted to compare the effect of popliteus muscle release and patellofemoral mobilization on pain intensity, function, and quadriceps muscle strength in patients with patellofemoral pain syndrome?

Tele-rehabilitation for Recreational Athletes With Patellofemoral Pain Syndrome

This study is a randomized clinical trial designed to evaluate the usability and effectiveness of a tele-rehabilitation program in recreational athletes with Patellofemoral Pain Syndrome (PFPS). A total of 26 participants aged 18-35 years with unilateral PFPS will be randomly allocated into either a conventional physiotherapy group or a tele-rehabilitation group. Both groups will receive the same evidence-based exercise protocol comprising stretching, strengthening, balance, and functional exercises over a four-week period; however, the intervention group will perform the exercises remotely using the Physitrack mobile application with regular virtual supervision and progress monitoring, while the control group will receive face-to-face physiotherapy sessions. Primary outcome measures will include pain intensity assessed by the Numerical Pain Rating Scale (NPRS), knee range of motion measured using a universal goniometer, and quality of life evaluated using the Knee Injury and Osteoarthritis Outcome Score (KOOS). The usability and patient satisfaction of the tele-rehabilitation platform will be assessed using the Telehealth Usability Questionnaire (TUQ). The findings of this study will determine whether tele-rehabilitation is a feasible, user-friendly, and effective alternative to conventional physiotherapy for improving clinical outcomes and rehabilitation accessibility in recreational athletes with PFPS.

Aquatic Plyometrics for Adolescents With Patellofemoral Pain Syndrome

This study was designed to assess the effect of a 12-week hydro-kinetic plyometric (HK-Plyo) training on pain, muscle strength, disability, and quality of life (QoL) in adolescents with patellofemoral pain syndrome (PFPS). Fifty-six adolescents with PFPS were randomly allocated to the HK-Plyo group (n = 28, received the plyometric-based hydro-kinetic therapy program, twice/week, over 12 weeks) or the control group (n = 28, received standard exercise program). Both groups were assessed for pain, muscle strength, disability, and QoL pre and post-treatment.

Vasti Control of Patellofemoral Kinematics in Asymptomatic Volunteer

Background: * Patellofemoral pain syndrome is one of the most common knee problems. It is characterized by pain in the front of the knee that is aggravated by deep knee flexion, prolonged sitting, and repetitive movement. The most widely accepted theory regarding the source of this pain is that a force imbalance around the knee puts extra stress on the area, leading to pain. * Researchers are interested in learning more about the muscle groups around the knee to better understand the causes of knee pain. Objectives: \- To obtain more information on how muscles, tendons, and bones work together to cause motion in the knee, both in the normal state and after immobilizing certain muscles around the knee. Eligibility: \- Healthy individuals between the ages of 18 and 55, who have no current or chronic muscle, bone, or joint problems and who have no implants or other problems that would prevent them from receiving a magnetic resonance imaging (MRI) scan. Design: * This protocol will be carried out over two visits, both of which will involve using standard MRI sequences to look at the knee at rest and in motion. * The first part will examine the knee under its natural state, with a standard MRI scan of the knee both at rest and in motion. * The second part will involve temporarily reducing the force producing capabilities of one of the extensor muscles in the knee. To do so, study doctors will inject lidocaine into the muscle, which will temporarily (for approximately 2 hours) block the force producing capacity of this muscle, and then perform the MRI scan.

Effects of Kinesio Taping Versus McConnell Taping on Clinical Outcomes in Patients With Patellofemoral Pain Syndrome.

The primary goal of this randomized clinical trial (RCT) is to evaluate whether Kinesio Taping versus McConnell Taping, when integrated into a standardized hip-knee strengthening and neuromuscular control program, produces significant effects in individuals aged 18-50 with patellofemoral pain syndrome (PFPS). The main question it aims to answer is: Does Kinesio Taping compared with McConnell Taping when both combined with a standardized hip-knee exercise program, produce different effects on quadriceps neuromuscular activation (VMO-VL sEMG), pain, functional knee pain, and dynamic knee valgus over a 6 week period intervention? Participants will be divided into three groups for comparison: the control group will receive a structured hip-knee physical therapy exercise program without any taping intervention, Kinesio Taping group with a standardized exercise program, and a McConnell Taping group with a standardized exercise program.

Core Stability Exercises Versus Proprioceptive Training on Pain and Function in Patients With Patellofemoral Pain Syndrome

This study will be conducted to investigate the effect of core stability exercises versus proprioceptive training in patients with patellofemoral pain syndrome.

High-Intensity Laser Acupuncture for Treating Patellofemoral Pain Syndrome

Patellofemoral pain syndrome (PFPS) is among the most prevalent forms of knee discomfort. The main complaint is typically anterior knee pain, which gets worse while jumping, bending knee, going up or down stairs, or sitting for long periods of time with bent knee. Teens and early adulthood are commonly affected by patellofemoral pain syndrome, with a higher frequency in females. In healthy general populations, the prevalence of patellofemoral pain syndrome is 22.7%, and in teens, it is 28.9%.

Comparative Effects Of Clamshell And Short Arc Quadriceps Exercises In Patellofemoral Pain

This is a research study to compare two different exercises for people who have patellofemoral pain syndrome. Patellofemoral pain syndrome means pain around or behind the kneecap, which is also called "runner's knee". People in this study will be divided into two groups by chance. One group will do clamshell exercises. This exercise strengthens hip muscles. The other group will do short arc quadriceps exercises. This exercise strengthens thigh muscles near the knee. Both groups will do their exercises for the same number of weeks. The main goal of this study is to see which exercise reduces knee pain better and helps patients do daily activities more easily. We will also check if quality of life improves after doing these exercises. Pain level, knee function, and quality of life will be checked before starting exercises and again after finishing the exercise program. The results may help doctors and physical therapists choose the best exercise for patients with kneecap pain.

Relationship Between Knee Pain And Proprioception During Single Leg Squat In Patellofemoral Pain Syndrome

This study will be conducted to investigate the relationship between knee joint pain intensity and joint position sense accuracy in patients with patellofemoral pain syndrome (PFPS) in a single-leg squat position.

Telerehabilitation vs. Conventional PT for Patellofemoral Pain Syndrome

Patellofemoral pain syndrome (PFPS) is one of the most common musculoskeletal disorders affecting approximately 25% of active young adults, and it is frequently associated with persistent anterior knee pain, functional limitations, and reduced quality of life. Despite the widespread use of conventional face-to-face physical therapy, many patients experience barriers related to accessibility, cost, and long-term adherence to rehabilitation programs

Popliteus Muscle Release Versus Kinesio Taping

The aim of the current study is to compare the effect of popliteus muscle release and Kinesio taping on pain intensity, function, dynamic balance, and quadriceps muscle strength in patients with patellofemoral pain syndrome.

Mindful Miles Pilot Feasibility Study

The goal of this single-arm pilot study is to examine the feasibility, acceptability, and preliminary efficacy of a progressive outdoor mindful physical activity intervention delivered via the Headspace mobile application for individuals with patellofemoral pain. AIM 1: Determine the feasibility and acceptability of the mindful activity intervention. AIM 2: Determine the preliminary efficacy of the mindful running intervention to improve the primary outcome of (2a) anterior knee pain, and secondary outcomes of (2b) kinesiophobia and (2c) running cadence and vertical forces (gait kinematics) in individuals with PFP. Our central hypothesis is that the intervention will be feasible and acceptable and will improve pain, kinesiophobia (injury-related fear), and running cadence (steps per minute) in individuals with patellofemoral pain. Participants will complete a three-phase progressive mindful physical activity intervention that involves: Phase 1: Introduction to mindfulness Phase 2: Guided mindful running Phase 3: Mindful running.

Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders

Lateral ankle sprain (LAS) and patellofemoral pain syndrome (PFPS) are common musculoskeletal conditions associated with postural instability. However, the direction-specific nature of balance deficits and comparative patterns across these conditions remain unclear. Therefore, the aim of this study is to compare overall, mediolateral, and anteroposterior postural stability indices among individuals with LAS, PFPS, and healthy controls using the Biodex Balance System

Stabilization vs Corrective Exercise in PFP

The purpose of this study is to investigate the effects of a Functional Stabilization training program (FST) and a comprehensive corrective exercise program in PF pain and DKV.

"Mulligan Technique vs Phonophoresis With Chitosan for Patellofemoral Pain"

Patellofemoral pain syndrome (PFPS) is a common knee condition causing pain and dysfunction. This study aims to compare the effectiveness of two physical therapy treatments for PFPS: Mulligan mobilization with movement technique versus phonophoresis with chitosan gel. Forty-five participants with patellofemoral pain syndrome will be randomly assigned to one of three groups: (1) Mulligan technique group, (2) Phonophoresis with chitosan gel group, or (3) Control group receiving standard physical therapy exercises. Each group will receive treatment 3 times per week for 4 weeks. The researchers want to determine which treatment is more effective in improving neuromuscular control, reducing pain, and improving function in patients with patellofemoral pain syndrome. Participants will be assessed before and after the treatment period. This study may help physical therapists and healthcare providers choose the most effective treatment approach for patients with patellofemoral pain.