Clinical Research Directory

Postural Decoding for Post-Stroke Shoulder Pain: A RCT.

Brief Summary Purpose of the Study: This clinical trial aims to determine whether Postural Decryption Technique can effectively treat hemiplegic shoulder pain (HSP) in patients recovering from stroke. It also seeks to assess the safety of this technique. The study will compare the effectiveness of the Postural Decryption Technique with traditional massage therapy to find out which method provides better pain relief and improves shoulder function. Key Research Questions: 1. Can the Postural Decryption Technique reduce shoulder pain and improve range of motion in HSP patients? 2. Is the Postural Decryption Technique more effective than traditional massage therapy? 3. Is the Postural Decryption Technique safe, and are there any side effects or discomfort during treatment? Study Design: 4. Researchers will recruit 48 participants with HSP and randomly divide them into two groups: Treatment Group: Participants will receive therapy using the Postural Decryption Technique. Control Group: Participants will undergo traditional massage therapy. What Participants Will Do: Receive treatment 5 times per week, 40 minutes per session, for 4 weeks. Undergo evaluations before treatment, 2 weeks after treatment begins, and at the end of 4 weeks to measure pain relief and shoulder function improvement. Undergo musculoskeletal ultrasound to assess changes in soft tissue and joint structure. Evaluation Methods: 1. Pain Assessment: Pain levels will be measured using the Visual Analog Scale (VAS). 2. Range of Motion (ROM): Tools will be used to measure the angles of shoulder movement. 3. Postural Assessment: The position of the scapula and spine will be measured to evaluate postural alignment improvements. 4. Daily Activity Ability: Progress in daily tasks will be recorded using the Barthel Index questionnaire. Significance of the Study: This study aims to validate whether the Postural Decryption Technique is a more effective and safer treatment for HSP compared to traditional massage therapy. If proven effective, it could offer a new rehabilitation approach to reduce pain, restore function, and improve the quality of life for stroke survivors. Safety Monitoring: Researchers will closely monitor participants for any signs of discomfort or adverse effects during the treatment process. Participants are free to withdraw from the study at any time if they experience any issues. Conclusion: The ultimate goal of this study is to identify a better treatment option for HSP in stroke patients. The results are expected to support the application of the Postural Decryption Technique as a safe and effective rehabilitation method for broader clinical use.

Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke

We are running a small, early-phase research study across several hospitals in Melbourne, Australia. The study will involve up to 100 young adults between the ages of 18 and 55 who have had a stroke. Our goal is to test how practical it is to carry out a detailed health assessment process-called "deep phenotyping"-with this group. This process involves collecting a wide range of information and samples from stroke survivors to better understand each participant's condition. We'll look at how well this approach works in practice, including how easy it is to use, whether it's done consistently, and how acceptable it is to participants. At the same time, we'll also explore how different factors-such as biological markers (biomarkers), age, sex, type of stroke, lifestyle, and environment-might be related to stroke recovery. This pilot study will help us prepare for larger studies in the future.

Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Stroke

This study will evaluate the effects of transcutaneous vagus nerve stimulation in combination with physical rehabilitation on upper limb motor function of patients with stroke.

Intracerebral Autologous Stem Cell Therapy for Chronic Stroke Patients

The goal of this clinical trial is to evaluate if autologous mesenchymal stem cell (HUNS001-01) transplantation therapy can provide neurological recovery in patients with chronic stage of stroke resulting in moderate to severe neurological sequelae. The main questions it aims to answer are: Can HUNS001-01 intracerebral transplantation demonstrate improvement in the mRS of disability for 1 year after intervention? Can HUNS001-01 intracerebral transplantation can be performed without any adverse events for 1 year after intervention? Participants will receive the below interventions. * Screening for the eligibility to enroll the clinical trial (interview, blood test, imaging) * Harvest of platelet concentrates (PC) * Harvest of bone marrows (BM) * Receive intracerebral transplantation surgery of HUNS001-01 * Post-operative rehabilitation * Follow-up studies (until 1 year or termination of the trial)