Clinical Research Directory

The Effect of Cognitive Exercise Therapy Approach and Yoga in Adolescents With Dysmenorrhoea

Dysmenorrhoea is a condition that negatively affects the quality of life in women of many age groups. In girls with dysmenorrhoea in adolescence, there is an effect on school performance, self-confidence-depression problems and a decrease in quality of life due to pain. In order to eliminate these negative effects, they should receive a good treatment. Medical treatment usually tries to minimise and balance this situation. Considering the fact that families do not want to use drugs such as oral contraceptives in their children at this age and the risks of oral contraceptives, parents are in different searches. Considering that the approach to pain should always be from a holistic perspective, yoga and cognitive exercise therapy approaches are both biopsychosocial treatment methods within the scope of mind-body integrity. Yoga and cognitive exercise therapy approach is thought to reduce symptoms, improve physical functions and quality of life in adolescent girls. With these positive effects, school absenteeism decreases, depression and self-confidence improve. Health costs will also be reduced to some extent.

Orem-Based Education for Dysmenorrhea Self-Care and Menstrual Hygiene in Adolescents

Background: Primary dysmenorrhea is common among adolescent girls and may adversely affect daily activities, school participation, and quality of life. Inadequate knowledge and self-care practices may complicate dysmenorrhea management and menstrual hygiene. Theory-based nursing interventions may support adolescents in developing appropriate self-care behaviors; however, evidence regarding interventions based on Orem's Self-Care Theory in this context remains limited. Aim: This study aimed to evaluate the effects of a supportive-educative nursing intervention based on Orem's Self-Care Theory on primary dysmenorrhea self-care and menstrual hygiene behaviors among adolescent girls. Methods: This single-blind, pretest-posttest, cluster-randomized controlled trial was conducted among adolescent girls. The intervention group received a six-session educational program delivered over four weeks and structured according to Orem's developmental self-care requisites and supportive-educative nursing system, while the control group continued routine school education. Data were collected using the Adolescent Dysmenorrhea Self-Care Scale and the Menstrual Hygiene Practices Questionnaire. Posttest assessments were conducted four weeks after completion of the intervention. Keywords: adolescent; dysmenorrhea; menstrual hygiene; Orem's Self-Care Theory; self-care; nursing education

Self-Acupressure for Primary Dysmenorrhea and Premenstrual Symptoms

This randomized, sham-controlled trial aims to evaluate the effects of self-administered acupressure on menstrual pain severity and premenstrual symptoms in women aged 18-30 years with primary dysmenorrhea. Participants will be randomly assigned to either a self-acupressure intervention group or a sham self-acupressure control group. The intervention will be applied during the premenstrual and menstrual periods over approximately six months. The primary outcome is the change in menstrual pain severity, and secondary outcomes include changes in premenstrual symptom severity, analgesic use, and menstruation-related activity limitation.

Exercise, Motor Imagery, and Pain Neuroscience Education for Primary Dysmenorrhea

The goal of this clinical trial is to find out whether exercise, motor imagery training, and pain neuroscience education can help reduce menstrual pain and improve well-being in young women with primary dysmenorrhea. The study will also look at how these approaches affect menstrual symptoms, movement control, and cognitive flexibility. The main questions it aims to answer are: * Does adding motor imagery or pain neuroscience education to an exercise program reduce pain and menstrual symptoms more than exercise alone? * Do these approaches improve movement control, thinking flexibility, and knowledge about pain? Researchers will compare three groups: * Exercise only * Exercise plus motor imagery training * Exercise plus pain neuroscience education Participants will: * Attend supervised exercise sessions twice a week for 8 weeks * Practice either motor imagery or receive short pain neuroscience education, depending on their group * Complete questionnaires and tests before and after the program, during the first three days of menstruation

Effect of a Magnesium Sulfate Footbath on Primary Dysmenorrhea Pain

Primary dysmenorrhea is a common condition characterized by painful menstruation. This three-arm randomized controlled trial evaluated the effect of a warm-water footbath containing magnesium sulfate on primary dysmenorrhea pain. A total of 120 women were randomized to a magnesium sulfate warm-water footbath group, a warm-water footbath group, or a no-intervention control group. Pain was assessed using the Short-Form McGill Pain Questionnaire and a Visual Analogue Scale at baseline, 20 minutes, 1 hour, and 2 hours after the intervention.

Evaluation of the Effect of a Structured Yoga Exercise in Young Women With Primary Dysmenorrhea

Abstract Primary dysmenorrhea is a common gynecological condition affecting women of reproductive age and negatively impacting quality of life. It is characterized by cramping pain in the lower abdomen that may radiate to the lower back and thighs, leading to decreased daily functioning, academic performance, and psychological well-being. In addition to pharmacological treatments, complementary approaches are increasingly used in the management of dysmenorrhea. Yoga, a mind-body exercise that combines physical movement with mental focus, has been suggested as an effective method for reducing stress and pain associated with dysmenorrhea. The aim of this study is to evaluate the level of awareness about dysmenorrhea in young women with primary dysmenorrhea and to investigate the effects of a yoga program on pain, quality of life, and menstrual attitudes following an educational session provided to all participants. Pain severity, quality of life, and menstrual attitudes will be assessed using validated questionnaires and scales, including the Visual Analog Scale (VAS), awareness questionnaire, functional and emotional dysmenorrhea scale, Menstrual Attitude Scale, and quality of life questionnaire. This study aims to determine whether yoga exercises reduce dysmenorrhea symptoms and improve quality of life in young women with primary dysmenorrhea. Additionally, the study is expected to increase awareness about dysmenorrhea and provide evidence for the effectiveness of yoga as a non-pharmacological intervention.

Evaluation of the Analgesic Effect of Intramyometrial Botulinum Toxin Injection Via Hysteroscopy in Pelvic Pain Suggestive of Dysmenorrhea

The objective of the study is to evaluate the global impression of improvement at 3 months following intramyometrial botulinum toxin injections via hysteroscopy in women with severe primary dysmenorrhea who have failed first-line medical treatment, compared to intramyometrial placebo injections.

Effect of Auricular Vagus Nerve Stimulation on Pain and Symptoms in Primary Dysmenorrhea

This study aims to investigate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on menstrual pain, pain threshold, depression, anxiety, menstrual symptoms, premenstrual syndrome, and functional and emotional impact of dysmenorrhea in young adult women with primary dysmenorrhea.

Primary Dysmenorrhea and Mobilization.

72 women diagnosed with primary dysmenorrhea were included in the study and divided into four groups. the first group received treatment with a mobilization approach, the second group received motor imagery-focused exercises and the third group, as a electrotherapy group and fourth received no treatment was applied.

Connective Tissue Massage and Music-Based Progressive Muscle Relaxation in Primary Dysmenorrhea

This randomized controlled clinical trial aims to investigate the effects of Connective Tissue Massage (CTM) and music-based Progressive Muscle Relaxation Training (PMRT) on pain intensity, pressure pain threshold, analgesic use, and menstruation-related symptoms in women with primary dysmenorrhea. Participants will be randomly assigned to one of three groups: CTM, music-based PMRT, or control. Baseline assessment will be conducted during menstrual days 1-2 of Cycle 0. The interventions will be applied during the premenstrual intervention window of Cycle 0, from the estimated ovulation day, calculated as cycle length minus 14 days, until Cycle 1 Day 1. Post-intervention assessment will be conducted during menstrual days 1-2 of Cycle 1. No intervention will be applied after the post-intervention assessment, and follow-up assessment will be conducted during menstrual days 1-2 of Cycle 2. Outcomes including pain intensity, pressure pain threshold, analgesic use, menstrual symptoms, attitudes toward menstruation, functional and emotional impact of dysmenorrhea, and pain catastrophizing will be evaluated across menstrual cycles. Participant satisfaction and adherence to the interventions will also be assessed.

Effect of Semiconductor Embedded Wearable Sleeve on Treatment of Primary Dysmenorrhea Symptoms

This study is looking to test a non-compressive semiconductor embedded body sleeve for treatment of primary dysmenorrhea symptoms. Dysmenorrhea is the lower abdominal pain (sometimes referred to as "cramping") experienced during menstruation (monthly "period"), affecting up to 94% of people aged from 10-20 years old. The semiconductor embedded fabric increases blood circulation through activation of the embedded elements with body heat while worn and releases energy waves as well as negative ions. This energy has an effect inside the body that increases oxygen and nutrient flow to tissues, and can help to decrease pain and inflammation. This study is testing this technology to see if it can be used as a non-pharmacological treatment for menstrual cramping.

Effect of Lifestyle Modification on Obese Females With Primary Dysmenorrhea

The study will be designed to determine the effect of lifestyle modification on primary dysmenorrhea in obese females.

Immediate Effects of Kinesio Taping in Primary Dysmenorrhea

Primary dysmenorrhea is characterized by recurrent, cramping lower abdominal pain during menstruation and affects approximately 50% to 90% of women. The etiology of primary dysmenorrhea involves the increased release of prostaglandins and other inflammatory mediators, which cause uterine contractions and reduced blood flow. In addition to pharmacological approaches, non-pharmacological methods also play an important role in the treatment of dysmenorrhea. Kinesio taping helps relieve pain by reducing pressure on the muscle and supports treatment through various application techniques. It improves local circulation, reduces muscle tension, and alleviates symptoms of primary dysmenorrhea. The aim of this study is to investigate the effects of kinesio taping on pain, menstrual symptoms, fear of movement, and sleep quality in women with primary dysmenorrhea, and to compare the outcomes with those of a sham taping group. The hypothesis is that kinesio taping will be more effective than sham taping in improving these parameters in women with primary dysmenorrhea.

Spinal Manipulation For Menstrual Symptoms and Sleep in Individuals With Primary Dysmenorrhea

The goal of this observational study is to evaluate if spinal manipulation (SM) combined with connective tissue massage (CTM) improves pain, menstrual symptoms, depression levels, and sleep quality in women with primary dysmenorrhea (PD). The main questions it aims to answer are: Null Hypothesis (H0): SM has no effect on primary dysmenorrhea symptoms, pain severity, depression levels, or sleep quality. Alternative Hypothesis (H1): SM has a significant effect on primary dysmenorrhea symptoms, pain severity, depression levels, and sleep quality. Researchers will compare three groups to determine if the combined intervention improves menstrual health: An intervention group receiving both CTM and SM applied to the abdominal and lumbar areas, A sham group receiving CTM with a sham SM procedure, A control group receiving no intervention. Participants will: Undergo three weekly sessions for one menstrual cycle (approximately three weeks), continuing for two cycles (six weeks total), Complete assessments on pain (VAS), menstrual symptoms (Menstrual Symptom Questionnaire), depression (Beck Depression Inventory), and sleep quality (Pittsburgh Sleep Quality Index) at the study's start and conclusion. This study aims to provide new insights into the combined effects of KDM and SM on menstrual health, potentially guiding future rehabilitation interventions for PD.

Primary Dysmenorrhea and Comfort Theory

Dysmenorrhea is defined as lower abdominal pain experienced during menstruation. It is divided into two types: primary dysmenorrhea and secondary dysmenorrhea. In young women, the majority of dysmenorrhea cases are primary dysmenorrhea. Primary dysmenorrhea has a physical, psychological, and social impact on young women. Pharmacological and non-pharmacological methods are used to treat primary dysmenorrhea. Education is important in increasing the effectiveness of primary dysmenorrhea treatment. An effective education process takes place in accordance with nursing theories and models. There are a limited number of studies on the effect of comfort theory-based education in the management of primary dysmenorrhea. In this research, planned as a randomized controlled trial, the intervention group will receive comfort theory-based education, while the control group will receive no intervention. This study aims to contribute to the literature by investigating the effect of comfort theory-based education on dysmenorrhea, menstrual symptoms, premenstrual syndrome, and general well-being in university students with primary dysmenorrhea.

Transcutaneous Tibial Nerve Stimulation on Women With Primary Dysmenorrhea

This study aims to investigate the effects of transcutaneous tibial nerve stimulation (TTNS) on women with primary dysmenorrhea (PD).

Impact of Primary Dysmenorrhea on Academic Performance and Quality of Life Among Medical Students at Sohag University

Pain is an unpleasant sensation that negatively affects individual experiencing it, depending on its quality, intensity, location, and duration. One of the causes of pain among females is dysmenorrhea. Dysmenorrhea is defined as pain during menstruation. A significant population of females experience mild, moderate or severe pain during menstruation. Primary dysmenorrhea is defined as dysmenorrhea with the absence of any organic pathology starting 6-12 months after the menarche and frequently continuing till menopause, while secondary dysmenorrhea results from gynecologic problems such as adenomyosis, endometriosis, uterine fibroid and others.

Comparison of Pain, Physical, and Psychosocial Parameters in Women With and Without Primary Dysmenorrhea

Dysmenorrhea is a common gynecological condition that negatively affects women's physical, psychological, and social well-being. Primary dysmenorrhea (PD) has been associated with reduced pain thresholds in various body regions; however, evidence regarding its relationship with joint mobility, respiratory muscle strength, and psychosocial factors remains limited. In addition, the influence of menstrual attitudes, physical activity habits, and depressive symptoms in women with PD has not been sufficiently explored. Therefore, this study aims to compare women with and without primary dysmenorrhea in terms of pain threshold, joint mobility, physical activity level, respiratory muscle strength, menstrual attitudes, and depressive symptoms. Identifying the parameters affected by PD is essential for developing effective management strategies and may contribute to increased awareness and improved clinical approaches for primary dysmenorrhea.

Effect of Transcutaneous Tibial Nerve Stimulation on Primary Dysmenorrhea

This study will be conducted to evaluate the effect of Transcutaneous Tibial Nerve Stimulation (TTNS) on primary dysmenorrhea.

"Knee Joint Position Sense and Dynamic Balance in Females With Primary Dysmenorrhea

The purpose of the study is to assess knee joint position sense, pain and dynamic balance in female with primary dysmenorrhea.

Efficacy and Safety of CDE100 in the Treatment of Menstrual Cramp Pain Associated With Primary Dysmenorrhea

The purpose of this study if to evaluate the efficacy and safety of CDE100 in the Treatment of Menstrual Cramp Pain Associated With Primary Dysmenorrhea.

Effect of Primary Dysmenorrhea on Muscle Activity in Young Adult Females

This study aims to investigate the effect of primary dysmenorrhea on the activity of the abdominal and back muscles in young adult females.

Effects of Chamomile With L-theanine Beverage Among Young Women Experiencing Primary Dysmenorrhea

This study aims to evaluate the effects of a beverage containing chamomile and L-theanine on menstrual symptoms, pain intensity, mood, and sleep quality among young adult females with primary dysmenorrhea.

Effect of Virtual Reality on Prostaglandin Levels in Adolescent Females With Primary Dysmenorrhea

This study will be conducted to study the effect of virtual reality therapy on prostaglandin levels in adolescent females with primary dysmenorrhea.